Transcriptional factors, Mafs and their biological roles

Transcriptional Silencing Elements and Their Binding Factors

Fission Yeast CSL Transcription Factors: Mapping Their Target Genes and Biological Roles

BACKGROUND Cbf11 and Cbf12, the fission yeast CSL transcription factors, have been implicated in the regulation of cell-cycle progression, but no specific roles have been described and their target genes have been only partially mapped. METHODOLOGY/PRINCIPAL FINDINGS Using a combination of transcriptome profiling under various conditions and genome-wide analysis of CSL-DNA interactions, we id...

Long Non-coding RNAs and Their Biological Roles in Plants

With the development of genomics and bioinformatics, especially the extensive applications of high-throughput sequencing technology, more transcriptional units with little or no protein-coding potential have been discovered. Such RNA molecules are called non-protein-coding RNAs (npcRNAs or ncRNAs). Among them, long npcRNAs or ncRNAs (lnpcRNAs or lncRNAs) represent diverse classes of transcripts...

Genotype and phenotype of COVID-19: Their roles in pathogenesis

COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence th...

Organisational Factors and their Roles in Creating IT Business Value

Research on business value of information technology (IT) has recognised that organisational factors play critical roles in affecting how IT impacts on firm performance. However, the conceptualisation of organisational factors and their relationship with IT and firm performance has not been extensively developed in the literature. There is neither a coherent way of specifying organisational fac...